Is biology better at computing than supercomputers?

Stimulated by discussions about the physics of learning machines with Gerard Milburn, I have been wondering about biomolecular machines such as proteins that do the transcription and translation of DNA in protein synthesis. These are rather amazing machines.

I found an article which considers a problem that is simpler than learning, computation.

The thermodynamic efficiency of computations made in cells across the range of life

Christopher P. Kempes, David Wolpert, Zachary Cohen and Juan Pérez-Mercader

It considers the computation of translating a random set of 20 amino acids into a specific string for a specific protein. Actual thermodynamic values are compared to a generalised Landauer bound for computation. Below is the punchline. (page 9)

Given that the average protein length is about 325 amino acids for 20 unique amino acids, we have that p_i=p=1/20³²⁵=1.46×10⁻⁴²³, where there are 20³²⁵ states, such that the initial entropy is  , which gives the free energy change of kT(S_I−0)=4.03×10⁻¹⁸ (J) or 1.24×10⁻²⁰ (J per amino acid). This value provides a minimum for synthesizing a typical protein. 

We can also calculate the biological value from the fact that if four ATP equivalents are required to add one amino acid to the polymer chain with a standard free energy of 47.7 (kJ mol⁻¹) for ATP to ADP, then the efficiency is 1.03×10⁻¹⁶ (J) or 3.17×10⁻¹⁹ (J per amino acid).  

This value is about 26 times larger than the generalized Landauer bound.

These results illustrate that translation operates at an astonishingly high efficiency, even though it is still fairly far away from the Landauer bound. To put these results in context, it is interesting to note that the best supercomputers perform a bit operation at approximately 5.27×10⁻¹³ (J per bit). In other words, the cost of computation in supercomputers is about eight orders of magnitude worse than the Landauer bound of  (J) for a bit operation, which is about six orders of magnitude less efficient than biological translation when both are compared to the appropriate Landauer bound. Biology is beating our current engineered computational thermodynamic efficiencies by an astonishing degree.