The challenge of coupled electron-proton transfer

There is a nice helpful review
Biochemistry and Theory of Proton-Coupled Electron Transfer 
Agostino Migliore, Nicholas F. Polizzi, Michael J. Therien, and David N. Beratan

Here are a few of the (basic) things I got out of reading it (albeit on a long plane flight a while ago).

There are a diverse range of biomolecules where coupled electron-proton transfer plays a key role in their function. The electron transfer (ET) and proton transfer (PT) are usually spatially separated. [See blue and red arrows below].

There are fundamental questions about whether the transfer is concerted or sequential, adiabatic or non-adiabatic, and how important the protein environment (polar solvent)  is.

Often short hydrogen bonds are involved and so the nuclear degrees of freedom need to be treated quantum mechanically, in order to take into account tunnelling and/or zero-point motion.

Diabatic states are key to understanding and theoretical model development.

Although there are some "schematic" theories, they involve some debatable approximations (e.g. Fermi's golden rule), and so there is much to be done, even at the level of minimal model Hamiltonians.