There are two aspects to this question concerning the future of condensed matter physics. First, are there big things to be discovered? If yes, will they be discovered?
I believe the first answer is yes for two reasons. First, the past hundred years have given us a continual stream of discoveries, many of them unexpected. Every time that things get a little boring, pretty soon there is something exciting and new. Second, condensed matter physics is all about emergent phenomena in materials. Emergent phenomena are extremely hard to anticipate or predict. Because of the combinatorics of chemistry, the list of possible materials to study is endless. CMP presents an endless frontier to explore. However, just because such a frontier exists does not mean that it will be explored. Successful explorers require courage, creativity, resources, time, and freedom.
I am concerned that the wild frontiers of condensed matter may not be explored. It is worth reflecting on who were some of the pioneers of CMP and the character of their institutional environments. Consider Kammerlingh Onnes, Landau, Kapitsa, Anderson, de Gennes, and Leggett. Some common elements of the context (institutional, historical, political) in which they made their discoveries were time, stability, job security, mental space, and intellectual freedom. For example, Anderson spent almost three decades at Bell Labs in its heyday. Thanks to the monopoly of Bell in providing telephone services in the USA, the parent company had a very secure and stable income, providing it the ability to provide substantial financial and institutional support for basic research.
These pioneers played a long game. They had the freedom to fail, to choose research topics, and to change directions. They did not follow fashion and were fiercely independent thinkers. Andrew Zangwill highlights this about Anderson in his biography. They largely had the resources they needed and did not have to worry or fight for funding. Their daily life was very different from that of a researcher today. Their mental space was not filled with an endless stream of distractions such as emails, grant proposals, conferences, reporting, reviewing, committees, metrics, ... Most of their time and mental energy was simply focused on curiosity-driven research.
Today, there is intense competition for funding, institutional status, and career benefits associated with obtaining it, and a pressure to produce in the short term "outputs" (papers) and "impact" (citations) and "national benefit" (technological, commercial, security, and social). This naturally leads to researchers working on "safe" projects in fashionable areas that they are confident will produce results in the short term.
I hope that I am wrong. But, I fear that great discoveries may be missed.