It is very rare that physics is the centre of a play, particularly anything that receives popular or critical acclaim. An exception is the play, Copenhagen by Michael Frayn. It centres around the famous meeting between Heisenberg and Bohr, in Nazi-occupied Copenhagen in 1941.
I enjoyed watching the film version produced by the BBC. Daniel Craig [of James Bond fame] plays Werner Heisenberg. It nicely captures the complexities of not just Heisenberg's visit, but also that of the relationship between Heisenberg and his mentor, the role of Bohr's wife, the passion for physics, and the moral issues associated with nuclear weapons.